Abstract
Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry
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Amides / pharmacology*
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Analgesics, Opioid / chemistry*
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Analgesics, Opioid / pharmacology*
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Animals
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Benzofurans / chemistry
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Chromans / chemical synthesis
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Chromans / chemistry
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Chromans / pharmacology*
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Humans
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Receptors, Opioid, kappa / agonists*
Substances
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Amides
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Analgesics, Opioid
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Benzofurans
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Chromans
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Receptors, Opioid, kappa
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coumaran